C-type lectins in antifungal immunity (360G-Wellcome-102705_Z_13_Z)
Over the last decade, in research funded primarily by the Wellcome Trust, my group hasestablished that C-type lectin receptors (CLRs) are critical for protective antifungal immunity [1].Yet our understanding of the roles of these receptors remains in its infancy, despite thetherapeutic potential that this knowledge could offer. Over the next five years, I will build on ourexciting recent observations to answer three fundamentally important questions:I. Which systems driven by Dectin-1 and other myeloid-expressed CLRs are required forprotective antifungal immunity?II. How does costimulation of CLRs with other pattern recognition receptors (PRRs)mediate protective immunity and pathology?III. Does MelLec and other epithelial cell CLRs contribute to antifungal immunity?
Where is this data from?
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Grant Details
Amount Awarded | 2219410 |
Applicant Surname | Brown |
Approval Committee | Science Interview Panel |
Award Date | 2013-12-03T00:00:00+00:00 |
Financial Year | 2013/14 |
Grant Programme: Title | Investigator Award in Science |
Internal ID | 102705/Z/13/Z |
Lead Applicant | Prof Gordon Brown |
Partnership Value | 2219410 |
Planned Dates: End Date | 2019-08-31T00:00:00+00:00 |
Planned Dates: Start Date | 2014-09-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Scotland |