C-type lectins in antifungal immunity (360G-Wellcome-102705_Z_13_Z)

£2,219,410

Over the last decade, in research funded primarily by the Wellcome Trust, my group hasestablished that C-type lectin receptors (CLRs) are critical for protective antifungal immunity [1].Yet our understanding of the roles of these receptors remains in its infancy, despite thetherapeutic potential that this knowledge could offer. Over the next five years, I will build on ourexciting recent observations to answer three fundamentally important questions:I. Which systems driven by Dectin-1 and other myeloid-expressed CLRs are required forprotective antifungal immunity?II. How does costimulation of CLRs with other pattern recognition receptors (PRRs)mediate protective immunity and pathology?III. Does MelLec and other epithelial cell CLRs contribute to antifungal immunity?

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Grant Details

Amount Awarded 2219410
Applicant Surname Brown
Approval Committee Science Interview Panel
Award Date 2013-12-03T00:00:00+00:00
Financial Year 2013/14
Grant Programme: Title Investigator Award in Science
Internal ID 102705/Z/13/Z
Lead Applicant Prof Gordon Brown
Partnership Value 2219410
Planned Dates: End Date 2019-08-31T00:00:00+00:00
Planned Dates: Start Date 2014-09-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Scotland