Regulation of intestinal immune homeostasis by NOD-like receptors. (360G-Wellcome-102972_Z_13_Z)
How do innate immune pathways in mammalian hosts determine the level of danger posed by a particular intestinal microbe and respond appropriately? How do innate immune receptors, particularly the inflammasome forming NOD-like receptors (NLR), regulate intestinal homeostasis? How does NLR sensing by intestinal epithelial cells (IEC) contribute to protection and pathology in the intestine? How do different innate immune circuits intersect to regulate host defence and inflammation in the g ut? How does inflammasome activation influence T cell homeostasis in the gut?
Where is this data from?
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Grant Details
Amount Awarded | 1878290 |
Applicant Surname | Maloy |
Approval Committee | Science Interview Panel |
Award Date | 2013-12-03T00:00:00+00:00 |
Financial Year | 2013/14 |
Grant Programme: Title | Investigator Award in Science |
Internal ID | 102972/Z/13/Z |
Lead Applicant | Prof Kevin Maloy |
Partnership Value | 1878290 |
Planned Dates: End Date | 2020-02-13T00:00:00+00:00 |
Planned Dates: Start Date | 2014-09-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South East |