Regulation of intestinal immune homeostasis by NOD-like receptors. (360G-Wellcome-102972_Z_13_Z)

£1,878,290

How do innate immune pathways in mammalian hosts determine the level of danger posed by a particular intestinal microbe and respond appropriately? How do innate immune receptors, particularly the inflammasome forming NOD-like receptors (NLR), regulate intestinal homeostasis? How does NLR sensing by intestinal epithelial cells (IEC) contribute to protection and pathology in the intestine? How do different innate immune circuits intersect to regulate host defence and inflammation in the g ut? How does inflammasome activation influence T cell homeostasis in the gut?

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Grant Details

Amount Awarded 1878290
Applicant Surname Maloy
Approval Committee Science Interview Panel
Award Date 2013-12-03T00:00:00+00:00
Financial Year 2013/14
Grant Programme: Title Investigator Award in Science
Internal ID 102972/Z/13/Z
Lead Applicant Prof Kevin Maloy
Partnership Value 1878290
Planned Dates: End Date 2020-02-13T00:00:00+00:00
Planned Dates: Start Date 2014-09-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East