Inhibitors of Lysyl Oxidase for the Prevention and Treatment of Invasive and Metastatic Cancer (360G-Wellcome-103021_Z_13_D)
The enzyme lysyl oxidase (LOX) regulates cross-linking of structural proteins in the extracellular matrix. LOX also plays a role in stimulating the metastatic spread of cancer through the body. Its expression is increased in hypoxic cancers and is correlated with tumour metastasis and decreased patient survival. In model systems its inhibition significantly decreases cancer metastasis and increases survival. Since metastasis is responsible for over 90 per cent of cancer deaths these data validate LOX as an important therapeutic target in cancer. Professor Caroline Springer and Professor Richard Marais from the Institute of Cancer Research have been awarded Seeding Drug Discovery funding to develop drugs that target LOX. They are applying a medicinal chemistry drug discovery approach underpinned by a strong programme in LOX biology with the aim of producing orally available, small molecular weight drugs that inhibit LOX activity for cancer treatment.
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
| Amount Awarded | 183502 |
| Applicant Surname | Springer |
| Approval Committee | Internal Decision Panel for C&S |
| Award Date | 2016-07-30T00:00:00+00:00 |
| Financial Year | 2015/16 |
| Grant Programme: Title | Seeding Drug Discovery Award |
| Internal ID | 103021/Z/13/D |
| Lead Applicant | Prof Caroline Springer |
| Other Applicant(s) | Dr Naureen Starling, Prof David Cunningham, Prof Richard Marais |
| Partnership Value | 183502 |
| Planned Dates: End Date | 2016-12-13T00:00:00+00:00 |
| Planned Dates: Start Date | 2014-09-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |