Understanding the role of sugar transporters in Mycobacterium tuberculosis. (360G-Wellcome-104193_Z_14_Z)

£822,993

There is currently a lack of understanding of the role of the sugar transport systems in Mycobacterium tuberculosis. The aim of the project is to elucidate the role of these sugar transporters in Mtb by undertaking an interdisciplinary state-of-the-art biochemical, chemical and genetic approach. In this project proteins involved in the uptake of sugars will be recombinantly expressed with the goal of biochemically characterizing the specific substrates that bind and determining the crystal struc ture of these proteins in complex with their physiological ligands, with a view to developing inhibitors of these systems. In parallel a series of mutants of genes involved in sugar uptake will be generated in order to assess the functional role of the transporters and the effects of these mutations determined in vitro by tracking the accumulation of sugars and their incorporation into the cell wall of mycobacteria and in vivo in mice to understand their role in virulence and infection. The mai n goals are: 1) Biochemical characterization and structural determination of the enzymes involved in sugar uptake. 2) Assign physiological functions to genes involve in sugar transport by generating null and conditional mutants in mycobacteria.

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Grant Details

Amount Awarded 822993
Applicant Surname Fullam
Approval Committee Sir Henry Dale Fellowship Interview Committee
Award Date 2014-06-04T00:00:00+00:00
Financial Year 2013/14
Grant Programme: Title Sir Henry Dale Fellowship
Internal ID 104193/Z/14/Z
Lead Applicant Dr Elizabeth Fullam
Partnership Name Royal Society/Wellcome Trust Sir Henry Dale Fellowship
Partnership Value 822993
Planned Dates: End Date 2024-06-30T00:00:00+00:00
Planned Dates: Start Date 2014-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region West Midlands
Sponsor(s) Prof John McCarthy