Investigation of an essential enzyme involved in sugar processing in Mycobacterium tuberculosis (360G-Wellcome-104193_Z_16_A)
There is currently a lack of understanding of the role of the sugar transport systems in Mycobacterium tuberculosis. The aim of the project is to elucidate the role of these sugar transporters in Mtb by undertaking an interdisciplinary state-of-the-art biochemical, chemical and genetic approach. In this project proteins involved in the uptake of sugars will be recombinantly expressed with the goal of biochemically characterizing the specific substrates that bind and determining the crystal struc ture of these proteins in complex with their physiological ligands, with a view to developing inhibitors of these systems. In parallel a series of mutants of genes involved in sugar uptake will be generated in order to assess the functional role of the transporters and the effects of these mutations determined in vitro by tracking the accumulation of sugars and their incorporation into the cell wall of mycobacteria and in vivo in mice to understand their role in virulence and infection. The mai n goals are: 1) Biochemical characterization and structural determination of the enzymes involved in sugar uptake. 2) Assign physiological functions to genes involve in sugar transport by generating null and conditional mutants in mycobacteria.
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Grant Details
Amount Awarded | 94809 |
Applicant Surname | Fullam |
Approval Committee | Science Enhancement Committee |
Award Date | 2016-02-11T00:00:00+00:00 |
Financial Year | 2015/16 |
Grant Programme: Title | Enhancement |
Internal ID | 104193/Z/16/A |
Lead Applicant | Dr Elizabeth Fullam |
Partnership Value | 94809 |
Planned Dates: End Date | 2018-08-31T00:00:00+00:00 |
Planned Dates: Start Date | 2016-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | West Midlands |