Wellcome Trust Clinical PhD Programme at the University of Dundee: "Genomic investigation into evolution of Staphylococcus aureus and the micro-epidemiology of Staphylococcus aureus in atopic eczema." (360G-Wellcome-104241_Z_14_Z)

£243,031

Across all continents Staphylococcus aureus is the commonest cause of skin and soft tissue infection. Surface displayed and secreted proteins are fundamental for the ability of this bacterium to colonise and infect human hosts. Such secreted factors confer this organism’s ability to adhere to host cells and evade the immune system. The Type VII protein secretion system (T7SS) in S. aureus is emerging as an important system that contributes to disease-causing mechanism for this human pathogen. It has previously been shown that inactivation of the Type VII system in S. aureus (or equivalent in Mycobacterium) reduces pathogenicity. As of yet the precise function of this secretory system is still not fully understood. The aim of this work is directed towards determining the role the T7SS plays in human skin colonisation and the potential role it has in infection. This will be achieved by studying both T7SS wild type and mutant strains in models of skin infection (murine) and colonisation (ex-vivo human tissue culture). Once the involvement of the T7SS in these models in confirmed we will examine the contribution of the secreted substrates with human cells.

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Grant Details

Amount Awarded 243031
Applicant Surname Harkins
Approval Committee PhD Studentships
Award Date 2014-04-14T00:00:00+00:00
Financial Year 2013/14
Grant Programme: Title PhD Training Fellowship for Clinicians
Internal ID 104241/Z/14/Z
Lead Applicant Dr Catriona Harkins
Partnership Value 243031
Planned Dates: End Date 2016-12-01T00:00:00+00:00
Planned Dates: Start Date 2013-09-02T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Scotland
Sponsor(s) Prof Doreen Cantrell