Chronic irritability in ADHD: examining clinical and genetic links with depression. (360G-Wellcome-104408_Z_14_Z)

£196,865

ADHD is a common, impairing neurodevelopmental disorder associated with poor outcomes. It is frequently comorbid with depression, which develops after the onset of ADHD. Identifying children with ADHD at risk of later depression provides opportunity for early intervention. Children with ADHD and chronic irritability are a potential at risk group. In population studies irritability has been shown to predict depression, and a genetic relationship between irritability and depression has been found. Although irritability is a common feature of ADHD, its contribution to depression is yet to be fully explored within an ADHD population. The key aims of this proposal are to test whether children with ADHD and chronic irritability represent a subgroup at increased risk of later depression, and whether presence of chronic irritability in ADHD indexes higher genetic loading for depression. These aims will be addressed using a large clinical ADHD sample. Comparisons will be made between children with and without chronic irritability in terms of later depression, family history of depression and molecular genetic loading for depression. Findings will be expanded upon using a longitudinal population sample, to establish whether irritability cuts across diagnostic boundaries increasing risk of depression in a broad group of child neurodevelopmental disorders.

Where is this data from?

This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.

Grant Details

Amount Awarded 196865
Applicant Surname Eyre
Approval Committee Clinical Interview Committee
Award Date 2014-06-25T00:00:00+00:00
Financial Year 2013/14
Grant Programme: Title Research Training Fellowship
Internal ID 104408/Z/14/Z
Lead Applicant Dr Olga Eyre
Partnership Value 196865
Planned Dates: End Date 2018-12-31T00:00:00+00:00
Planned Dates: Start Date 2014-09-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Wales
Sponsor(s) Prof Anita Thapar