FunVar: Impacts of Genetic Variations on Protein Functions and Functional Pathways. (360G-Wellcome-104960_Z_14_Z)

£536,722

We will maintain and extend our integrated resources by developing new computational platforms. FunVar will analyse the impacts of genetic variants on the structures/functions of proteins and the networks in which they participate. DISASTR will exploit FunVar to provide web-based reports of impacts for all known, human, disease-associated variants. This will require development and further integration of our resources CATH-Gene3D (Orengo group), a unique, internationally renowned domain stru cture classification, with the functional resources of the Thornton group. CATH-Gene3D classifies ~30 million protein sequences into evolutionary superfamilies and provides information on functions (eg GO). It also describes biological roles by reporting protein interactions/networks. Functional resources in the Thornton group provide complementary data eg protein-ligand interactions (PDBsum) and catalytic residues (CSA). We will provide a unique perspective by focusing on domain structu re and accurately considering the functional role of the domain in its biological context eg complexes/networks. Our resources are unique in classifying domains into functional families. DISASTR will be a new and unique catalogue reporting structural/functional impacts for publicly available genetic variations linked to classified diseases. We will also establish a FunVar webserver for clinicians/biomedical researchers to learn the impacts of novel variants.

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Grant Details

Amount Awarded 536722
Applicant Surname Orengo
Approval Committee Multi-User Equipment Committee (inactive)
Award Date 2014-06-25T00:00:00+00:00
Financial Year 2013/14
Grant Programme: Title Biomedical Resources Grant
Internal ID 104960/Z/14/Z
Lead Applicant Prof Christine Orengo
Other Applicant(s) Dr Roman Laskowski, Prof Janet Thornton
Partnership Value 536722
Planned Dates: End Date 2021-06-30T00:00:00+00:00
Planned Dates: Start Date 2014-11-24T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London