Using next generation chromatin conformation capture approaches to study the dynamics and (360G-Wellcome-105281_Z_14_A)

£20,830

Gene expression is controlled by complex networks of regulatory elements in the genome, involving promoters, enhancers, silencers and insulator elements. Chromatin conformation capture methods can be used to analyse these cis-acting networks by measuring the physical interactions between the regulatory elements involved. Recently, a high-throughput approach, Capture-C, has been developed, that can be used to analyse such networks for hundreds of loci in the genome, at high resolution, in a single experiment. This project aims to use novel variants of Next Generation Capture-C to study (1) the dynamics of regulatory networks in different stages of haematopoiesis and (2) the three-dimensional structure of the genome.

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Grant Details

Amount Awarded 20830
Applicant Surname Oudelaar
Approval Committee Internal Decision Panel for C&S
Award Date 2016-09-30T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title PhD Studentship (Basic)
Internal ID 105281/Z/14/A
Lead Applicant Miss Aukje Oudelaar
Partnership Value 20830
Planned Dates: End Date 2018-09-30T00:00:00+00:00
Planned Dates: Start Date 2014-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East
Sponsor(s) Prof Jonathan Flint