Using next generation chromatin conformation capture approaches to study the dynamics and (360G-Wellcome-105281_Z_14_A)
Gene expression is controlled by complex networks of regulatory elements in the genome, involving promoters, enhancers, silencers and insulator elements. Chromatin conformation capture methods can be used to analyse these cis-acting networks by measuring the physical interactions between the regulatory elements involved. Recently, a high-throughput approach, Capture-C, has been developed, that can be used to analyse such networks for hundreds of loci in the genome, at high resolution, in a single experiment. This project aims to use novel variants of Next Generation Capture-C to study (1) the dynamics of regulatory networks in different stages of haematopoiesis and (2) the three-dimensional structure of the genome.
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Grant Details
Amount Awarded | 20830 |
Applicant Surname | Oudelaar |
Approval Committee | Internal Decision Panel for C&S |
Award Date | 2016-09-30T00:00:00+00:00 |
Financial Year | 2015/16 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 105281/Z/14/A |
Lead Applicant | Miss Aukje Oudelaar |
Partnership Value | 20830 |
Planned Dates: End Date | 2018-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2014-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South East |
Sponsor(s) | Prof Jonathan Flint |