Allosteric modulators of nicotine acetylcholine receptors (360G-Wellcome-105345_Z_14_A)
Nicotinic acetylcholine receptors (nAChRs) are major excitatory neurotransmitters and have been implicated in a number of neurological and psychiatric disorders. The primary aim of the project will be to combine synthetic organic chemistry and pharmacological techniques to examine allosteric modulation of nAChRs. This will build upon recent work in the Sheppard and Millar labs at UCL and will also exploit a refined homology model of the a7 nAChR that was generated as part of a rotation project during the first year of this PhD studentship. It is anticipated that the generation of novel compounds, combined with computer docking studies and molecular pharmacological techniques, will enable a greater insight to be gained into the mechanism of action of nAChR allosteric modulators.
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Grant Details
| Amount Awarded | 2529 |
| Applicant Surname | Newcombe |
| Approval Committee | Internal Decision Panel for C&S |
| Award Date | 2016-09-30T00:00:00+00:00 |
| Financial Year | 2015/16 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 105345/Z/14/A |
| Lead Applicant | Mr Joseph Newcombe |
| Partnership Value | 2529 |
| Planned Dates: End Date | 2018-09-21T00:00:00+00:00 |
| Planned Dates: Start Date | 2014-09-22T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |
| Sponsor(s) | Prof Gabriel Waksman |