PArtner-provided HIV Self-Testing and Linkage (PASTAL) in antenatal care clinics: methodology and delivery of an adaptive cluster-randomised trial in Blantyre, Malawi. (360G-Wellcome-105828_Z_14_Z)

HIV remains a global public health problem with 2.3 million new infections in 2012. Efforts to eliminate paediatric HIV have greatly strengthened HIV testing and counselling (HTC) services in African antenatal care clinics (ANC). HTC is a critical step towards HIV care and prevention, with couple-based testing especially valuable in ANC. In Malawi, > 80% of pregnant women but only 15% of male partners undergo HTC. We have recently shown that self-testing (HIVST) is highly acceptable to men and can increase uptake of ART at population level. HIVST may need additional interventions to maximise uptake and subsequent HIV care/prevention services, such as financial incentives, or short messaging services. The wide range of potential interventions, and need for multiple direct comparisons pose methodological challenges in identifying optimal strategies. We propose to develop and apply novel methodologies to evaluate candidate interventions for male partner engagement for which current e vidence is promising but insufficient to proceed to Phase III trials. The broad objectives are to develop statistical methodology required to combine adaptive multi-arm multi-stage designs with cluster-randomized trial methodologies and to use these to identify most promising candidate interventions for encouraging HIVST with linkage by male partners of ANC attendees.

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Grant Details

Amount Awarded 235231
Applicant Surname Choko
Approval Committee International Interview Committee
Award Date 2014-11-24T00:00:00+00:00
Financial Year 2014/15
Grant Programme: Title International Training Fellowship
Internal ID 105828/Z/14/Z
Lead Applicant Mr Augustine Choko
Partnership Value 235231
Planned Dates: End Date 2018-09-30T00:00:00+00:00
Planned Dates: Start Date 2015-04-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North West
Sponsor(s) Prof David Lalloo, Prof Liz Corbett