Multidisciplinary studies in the ecology and epidemiology of cholera to predict epidemics. (360G-Wellcome-105927_Z_14_Z)

Epidemics of cholera due to toxigenic Vibrio cholerae annually cause more than 120,000 deaths and millions of cases worldwide. The central research theme in developing a meaningful cholera control strategy involves understanding the biology of the pathogen and identifying the key indicators that can be successfully integrated to develop a model for predicting the likelihood and the scale of cholera outbreaks in a given area, to allow for adequate public health measures. The specific questions to be addressed in this research are: 1. Where are the natural reservoirs of toxigenic Vibrio cholerae O1, in a cholera endemic area? 2. How can the reservoir of toxigenic V. cholerae O1 be best identified and monitored? 3. Which genetic and ecological factors enable the pathogen to persist in the aquatic reservoirs under adverse conditions? 4. Which natural factors stimulate V. cholerae O1 to periodically resuscitate from a dormant form and grow in number in their reservoirs? 5. Which innate factors enhance or diminish the infectivity and transmissibility of V. cholerae ? 6. How bacteriophages and mobile genetic elements influence the emergence of new pathogenic strains and the epidemiology of cholera ? 7. Do temporal genetic changes and microevolution of toxigenic V. cholerae influence the severity of disease ? 8. Which ecological and microbiological indicators can be integrated into a climate based predictive model to improve the capacity of the model to fore cast the occurrence and magnitude of cholera outbreaks ?

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Grant Details

Amount Awarded 1509505
Applicant Surname Faruque
Approval Committee Science Interview Panel
Award Date 2014-12-03T00:00:00+00:00
Financial Year 2014/15
Grant Programme: Title Investigator Award in Science
Internal ID 105927/Z/14/Z
Lead Applicant Prof Shah Faruque
Partnership Value 1509505
Planned Dates: End Date 2017-11-30T00:00:00+00:00
Planned Dates: Start Date 2015-05-01T00:00:00+00:00
Recipient Org: Country Bangladesh
Region International