Neural circuits underlying parental behaviour. (360G-Wellcome-106096_Z_14_Z)
The aim of my proposed research programme is to uncover the neural circuit logic underlying parental behaviour. Galanin-expressing (Gal+) neurons in the medial preoptic area (MPOA) were recently shown to control parental behaviour in male and female mice. At the initial stage of the project I will trace the axonal projections and presynaptic partners of MPOA Gal+ neurons and characterize the input-output relationships and functional diversity of this population in both sexes (Aim 1). Subsequentl y, I will use optogenetic stimulation to investigate which MPOA Gal+ target areas control parental behaviour and whether different MPOA Gal+ neurons control discrete aspects of parental behaviour, such as pup retrieval, grooming or nursing (Aim 2). Finally, I will perform high-resolution functional mapping of parenting circuits in virgin males and fathers to reveal how social experience affects the structure and function of these circuits (Aim 3). These experiments aim to obtain a mechanistic un derstanding of parental behaviour at the level of neural networks.
Where is this data from?
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Grant Details
Amount Awarded | 250000 |
Applicant Surname | Kohl |
Approval Committee | Basic Science Interview Committee |
Award Date | 2014-11-19T00:00:00+00:00 |
Financial Year | 2014/15 |
Grant Programme: Title | Sir Henry Wellcome Postdoctoral Fellowship |
Internal ID | 106096/Z/14/Z |
Lead Applicant | Dr Johannes Kohl |
Partnership Value | 250000 |
Planned Dates: End Date | 2016-06-30T00:00:00+00:00 |
Planned Dates: Start Date | 2015-12-17T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South West |
Sponsor(s) | Dr Michael Hastings |