A strategic vision to drive the control of enteric fever through vaccination (360G-Wellcome-106158_B_14_Z)

The overall aim of this strategic award is to provide the science to underpin the implementation of new vaccines for the control of enteric fever, uniquely, in different epidemiological settings in Africa and Asia. The vision described here will: Provide missing data on disease burden, antibiotic resistance and transmission needed to support and implement conjugate vaccines for enteric fever, using epidemiological data collection and application of knowledge from (para)typhoid human challenge models. Establish the host factors that determine susceptibility to enteric fever to inform vaccine implementation strategies. Provide a comprehensive approach to diagnostics to allow a more accurate assessment of disease burden, vaccine impact and to inform epidemiological models. Investigate the mechanisms of natural and vaccine-induced protection in human challenge models (UK), test in human-to-mouse studies, and validate in field settings (Nepal, Bangladesh and Malawi) and to develop correlates of protection for use in driving vaccine implementation. Model disease dynamics and the balance between direct and indirect vaccine impact in different settings using the biological and epidemiological data emerging from the programme Strengthen research capacity in enteric fever endemic regions of the world and provide the data for vaccine implementation advocacy