The origin and catabolism of genotoxic aldehydes and their impact on stem cell maintenance. (360G-Wellcome-106202_Z_14_Z)
We want to understand how tissue specific stem cells protect their genomes against endogenous DNA damage by aldehydes. This proposal is focused around three broad aims: Aim 1: How do organisms and cells remove genotoxic aldehydes? Aim 2: What is the identity and origin of endogenous genotoxic aldehydes? Aim 3: What is the nature of DNA damage caused by aldehydes and how is it repaired in somatic stem cells?
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Grant Details
| Amount Awarded | 1936782 |
| Applicant Surname | Patel |
| Approval Committee | Science Interview Panel |
| Award Date | 2014-12-03T00:00:00+00:00 |
| Financial Year | 2014/15 |
| Grant Programme: Title | Investigator Award in Science |
| Internal ID | 106202/Z/14/Z |
| Lead Applicant | Prof Ketan Patel |
| Partnership Value | 1936782 |
| Planned Dates: End Date | 2020-08-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2015-03-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South West |