Interferon and MX2 Mediated Control of HIV-1. (360G-Wellcome-106223_Z_14_Z)
The outcome of viral infection is determined by competition between the virus and its host, and in particular the balance between host-encoded dependency factors whose exploitation promote virus growth, and immune and inflammatory responses that control infection yet may also exacerbate disease pathology. Here, we outline experiments: to understand the principles that underpin the recently discovered capacity of the type-1 interferon (IFN) inducible protein MX2 (myxovirus resistance 2, or MXB) to inhibit human immunodeficiency virus type-1 (HIV-1) infection; to identify additional, novel interferon stimulated genes (ISGs) that regulate HIV-1 replication and to define their functions; and, to explore further the dynamic interplay between type-1 IFN and HIV-1 in the context of natural human infection. We will employ a collaborative and multi-disciplinary approach, blending virological, molecular genetic, cell biological, biochemical and structural biology methodologies, with the analys es of viral isolates and specimens from patients and informative interventional trials. Four inter-related Aims are proposed: Aim 1. Delineating MX2 structure-function Aim 2. MX2 interactions with cell and viral factors Aim 3. Screening for novel anti-viral ISGs Aim 4. Learning from viral evolution and in vivo interventions
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
Amount Awarded | 1822984 |
Applicant Surname | Malim |
Approval Committee | Science Interview Panel |
Award Date | 2014-12-03T00:00:00+00:00 |
Financial Year | 2014/15 |
Grant Programme: Title | Investigator Award in Science |
Internal ID | 106223/Z/14/Z |
Lead Applicant | Prof Michael Malim |
Partnership Value | 1822984 |
Planned Dates: End Date | 2021-10-30T00:00:00+00:00 |
Planned Dates: Start Date | 2015-05-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |