Large Scale Biomanufacture of a Monovalent Ebola MVA Vector and Heterologous Boosting of Primed Subjects in Mali and the UK (360G-Wellcome-106325_Z_14_A)

£1,050,000

Conversations between the principal investigator, The Wellcome Trust and various other parties have led to this application being submitted for fast track assessment. The goal is to demonstrate the safety and immunogenicity in UK and West African adults of a vaccine for the Zaire strain of Ebola virus that has shown significant promise in pre-clinical studies conducted at the NIH in collaboration with Okairos, now GSK. Demonstration of the safety and immunogenicity of this vaccine by November 2014 in about 140 subjects would provide WHO with the option of providing this vaccine to affected countries, particularly for use in health care workers, for whom no other intervention is currently available.

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Grant Details

Amount Awarded 1050000
Applicant Surname Hill
Approval Committee Ebola Trials Advisory Committee
Award Date 2014-12-19T00:00:00+00:00
Financial Year 2014/15
Grant Programme: Title Ebola Research Support Initiative
Internal ID 106325/Z/14/A
Lead Applicant Prof Adrian Hill
Partnership Name Ebola Research Support Initiative
Partnership Value 2100000
Planned Dates: End Date 2016-12-31T00:00:00+00:00
Planned Dates: Start Date 2014-12-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East