The role of the innate immune system in repair and regeneration following myocardial infarction. (360G-Wellcome-106334_Z_14_Z)
After myocardial infarction in the adult heart, a stereotyped innate immune response drives persistent inflammation, leading to impaired healing, scar formation, adverse remodelling and heart failure. In contrast, the murine neonatal heart heals by regeneration after injury, without scar or fibrosis. In both the adult and neonatal murine myocardium, the monocyte-macrophage system is central to control of inflammation and the switch to subsequent repair. The mechanisms by which the innate immune system mediates regeneration and/or repair following myocardial infarction is the focus of this project proposal. The specific aims are To define the effects of discrete monocyte-macrophage populations in mediating cardiac regeneration and/or repair following myocardial infarction To assess how signalling cross-talk between the heart and the monocyte-macrophage system modifies regeneration/repair following myocardial infarction
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
| Amount Awarded | 319816 |
| Applicant Surname | Cahill |
| Approval Committee | PhD Studentships |
| Award Date | 2014-08-28T00:00:00+00:00 |
| Financial Year | 2013/14 |
| Grant Programme: Title | PhD Training Fellowship for Clinicians |
| Internal ID | 106334/Z/14/Z |
| Lead Applicant | Dr Thomas Cahill |
| Partnership Value | 319816 |
| Planned Dates: End Date | 2017-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2014-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South East |
| Sponsor(s) | Prof Paul Klenerman |