The role of methionine oxidation in prion formation (360G-Wellcome-106507_Z_14_Z)
How prions form spontaneously without underlying infection or genetic change is poorly understood at the molecular level, yet if we are to develop effective preventative measures for human and animal amyloidoses, this mechanism must be established. Of particular importance is identifying what can trigger this event. One strong possibility is that oxidative damage of the non-prion form of a protein may be an important trigger influencing the formation of its heritable prion conformation. This project will examine how an oxidized protein goes on to form a prion using the yeast [PSI+] and [PIN+] model prions. The specific goals of the project are: i) to test whether methionine sulphoxide reductases (MSRs) can protect against spontaneous prion formation using MSR mutants and oxidative stress conditions. ii) to determine whether methionine oxidation can occur on nascent ribosome-associated polypeptides during protein synthesis. iii) To examine whether antioxidants localise to ribosomes to protect nascent proteins against oxidation. Additionally to determine whether antioxidants localize to the sites of protein aggregation as part of the cellular antioxidant defences
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
Amount Awarded | 150896 |
Applicant Surname | Schepers |
Approval Committee | PhD Studentships |
Award Date | 2014-09-15T00:00:00+00:00 |
Financial Year | 2013/14 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 106507/Z/14/Z |
Lead Applicant | Miss Jana Schepers |
Partnership Value | 150896 |
Planned Dates: End Date | 2018-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2014-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | North West |
Sponsor(s) | Prof Andrew Sharrocks |