Wellcome Trust PhD Programme for Clinicians at the University of Cambridge. (360G-Wellcome-106565_Z_14_Z)

£216,904

Parkinson's disease (PO) is common, affecting between 2-3% of people over the age of 65 with over half of patients developing dementia within ten years. This causes a decline in function and often leads to nursing home care. The involvement of the immune system in PO has been well described but it remains unclear whether this is an epiphenomenon. I hypothesise that the immune response to PO associated pathology contributes to disease progression, increasing the risk of dementia. My PhD will look at the role played by 8 lymphocytes as most research has focused on T lymphocytes or the innate immune system. I aim to characterise the 8 lymphocyte response associated with alpha synuclein pathology in both the mouse and human brain and to identify whether there are perturbations in the systemic 8 cell compartment in patients at high risk of dementia versus those who have a low risk. Using two mouse models of PO I will manipulate B cells to see whether 8cell depletion, antibody depletion or manipulation of 8 cell regulatory activity alters disease course thereby confirming causation in an animal model.

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Grant Details

Amount Awarded 216904
Applicant Surname Scott
Approval Committee PhD Studentships
Award Date 2014-09-15T00:00:00+00:00
Financial Year 2013/14
Grant Programme: Title PhD Training Fellowship for Clinicians
Internal ID 106565/Z/14/Z
Lead Applicant Dr Kirsten Scott
Partnership Value 216904
Planned Dates: End Date 2018-08-31T00:00:00+00:00
Planned Dates: Start Date 2014-12-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
Sponsor(s) Prof Krishna Chatterjee