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Diabetes and Inflammation Laboratory. (360G-Wellcome-107212_Z_15_Z)

Our goal is to identify clinical interventions in patients recently diagnosed with, or children at high risk of developing, type 1 diabetes (T1D), thereby maximising the health benefits of genetics and genomics in this common immune disorder. Our studies in T1D serve as a model for the investigation of other diseases and their treatment. We will take specific steps towards achieving this goal during the next five year programme: (1) Genetics. Define the genetic basis of T1D by fine-mapping di sease-associated causal variants and haplotypes, identify their target genes, and investigate the regulation of these genes before and after cell activation/differentiation. (2) Phenotypes and mechanisms. Identify aberrant cellular interactions and pathways caused by susceptibility genes that mediate a loss of immune tolerance to insulin-producing beta cells culminating in their destruction. These will provide potential targets for therapeutic intervention, as demonstrated by our work in the I L-2 pathway. (3) Experimental medicine. Complete our mechanistic investigations of the effects of IL-2 administration in patients, as a prelude to testing the efficacy of ultra-low dose IL-2 in the preservation of C-peptide and beta-cell function. Investigate, using the same mechanistic approach and depending on our emerging knowledge, another potential therapeutic.


21 Apr 2015

Grant details
Amount Awarded 8289795
Applicant Surname Todd
Approval Committee Strategic Awards Committee
Award Date 2015-04-21T00:00:00+00:00
Financial Year 2014/15
Grant Programme: Title Strategic Award - Science
Internal ID 107212/Z/15/Z
Lead Applicant Prof John Todd
Other Applicant(s) Dr Frank Waldron-Lynch, Prof Linda Wicker, Dr Chris Wallace
Planned Dates: End Date 2020-09-30T00:00:00+00:00
Planned Dates: Start Date 2015-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
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