Improving the management and prevention of tetanus in Vietnam. (360G-Wellcome-107367_Z_15_Z)

£569,168

Key Goal 1. To establish whether intrathecally administered antitoxin reduces the requirement for mechanical ventilation, and in addition reduces mortality, duration and cost of intensive care unit stay, duration of mechanical ventilation, requirement for antibiotics, and incidence of predefined nosocomial infection and autonomic nervous system dysfunction. I will perform a randomised-controlled trial of intrathecally administrated antitoxin in 270 adult patients, allocating patients to intrath ecal administration or sham procedure in addition to standard intramuscular antitoxin and routine care. Key Goal 2. To develop a simple prediction tool that can be applied clinically to allow early diagnosis and intervention in autonomic nervous system dysfunction. I will quantify heart rate variability in 60 patients with tetanus, correlating sequential readings with the development of autonomic nervous system dysfunction and outcome. Key Goal 3: To create an age/sex-stratified model o f population immunity in Vietnam to ascertain whether current booster programmes are adequate and what proportion of adults lack protection from tetanus. I will measure serum anti-tetanus antibody concentrations using enzyme-linked immunosorbent assay (ELISA) in 4000 serum samples from a recently-established serum bank containing samples from multiple sites in Southern Vietnam.

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Grant Details

Amount Awarded 569168
Applicant Surname Thwaites
Approval Committee Basic Science Interview Committee
Award Date 2015-04-13T00:00:00+00:00
Financial Year 2014/15
Grant Programme: Title Career Re-Entry Fellowship
Internal ID 107367/Z/15/Z
Lead Applicant Prof Catherine Thwaites
Partnership Value 569168
Planned Dates: End Date 2021-01-31T00:00:00+00:00
Planned Dates: Start Date 2015-08-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East
Sponsor(s) Prof Tran Hien