Improving the management and prevention of tetanus in Vietnam. (360G-Wellcome-107367_Z_15_Z)
Key Goal 1. To establish whether intrathecally administered antitoxin reduces the requirement for mechanical ventilation, and in addition reduces mortality, duration and cost of intensive care unit stay, duration of mechanical ventilation, requirement for antibiotics, and incidence of predefined nosocomial infection and autonomic nervous system dysfunction. I will perform a randomised-controlled trial of intrathecally administrated antitoxin in 270 adult patients, allocating patients to intrath ecal administration or sham procedure in addition to standard intramuscular antitoxin and routine care. Key Goal 2. To develop a simple prediction tool that can be applied clinically to allow early diagnosis and intervention in autonomic nervous system dysfunction. I will quantify heart rate variability in 60 patients with tetanus, correlating sequential readings with the development of autonomic nervous system dysfunction and outcome. Key Goal 3: To create an age/sex-stratified model o f population immunity in Vietnam to ascertain whether current booster programmes are adequate and what proportion of adults lack protection from tetanus. I will measure serum anti-tetanus antibody concentrations using enzyme-linked immunosorbent assay (ELISA) in 4000 serum samples from a recently-established serum bank containing samples from multiple sites in Southern Vietnam.
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Grant Details
Amount Awarded | 569168 |
Applicant Surname | Thwaites |
Approval Committee | Basic Science Interview Committee |
Award Date | 2015-04-13T00:00:00+00:00 |
Financial Year | 2014/15 |
Grant Programme: Title | Career Re-Entry Fellowship |
Internal ID | 107367/Z/15/Z |
Lead Applicant | Prof Catherine Thwaites |
Partnership Value | 569168 |
Planned Dates: End Date | 2021-01-31T00:00:00+00:00 |
Planned Dates: Start Date | 2015-08-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South East |
Sponsor(s) | Prof Tran Hien |