Public Engagement Provision (360G-Wellcome-107467_Z_15_A)
Delirium is one of the most common complications of acute illness in older adults yet it remains poorly understood. This fellowship will investigate prospectively population delirium incidence with cognitive outcomes. In parallel, I will test new methods for informatics-based delirium ascertainment for use in longitudinal studies. Hypothesis: Incident delirium is associated with changes in global cognitive scores (pre-delirium compared to scores at two-year follow-up). Methods I will recr uit a population-based cohort of 2,000 individuals aged 65 years and older. Participants will undergo baseline cognitive assessments. Then, participants will be proactively monitored for episodes of delirium, via: (i) telephone contact of highest-risk participants/informants (ii) daily screen of hospital admissions lists. Hospitalised participants will be assessed for delirium and associated clinical data. I will continue to assess cognitive function after discharge (four-monthly), with a whole- cohort assessment at 2 years. Reference-standard delirium diagnoses will be used to develop and validate algorithms for delirium ascertainment from electronic health records. Outcomes This study will be the first prospective population cohort relating delirium and its features to risk of long-term cognitive impairment. Validated informatics-based delirium measures will allow wide exploitation of clinically rich datasets for the enhancement of other prospective studies
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Grant Details
Amount Awarded | 25468 |
Applicant Surname | Davis |
Approval Committee | International Interview Committee |
Award Date | 2015-06-17T00:00:00+00:00 |
Financial Year | 2014/15 |
Grant Programme: Title | Provision for Public Engagement |
Internal ID | 107467/Z/15/A |
Lead Applicant | Dr Daniel Davis |
Partnership Value | 25468 |
Planned Dates: End Date | 2020-05-16T00:00:00+00:00 |
Planned Dates: Start Date | 2016-05-17T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |