Detecting tumour resistance to treatment with positron emission tomography. (360G-Wellcome-107610_Z_15_Z)
Ovarian cancer is the fifth leading cause of cancer-related deaths among women in the United States and Europe, making it one of the most common cancers affecting women. Ovarian cancer initially responds well to surgical resection and/or platinum-based chemotherapy, leaving the patient disease free. However, tumours often recur as lethal, platinum-resistant disease. Aldehyde dehydrogenase (ALDH) has been identified as a biomarker of chemoresistance in this patient population. I will develop nove l positron emission tomography (PET) imaging agents with high specificity and selectivity for visualising therapy resistance in preclinical models of ovarian carcinoma, based on the measurement of aldehyde dehydrogenase activity. Additional biomarkers of drug resistance, such as the drug efflux transporter MDP1, are also known to have a major impact on the pharmacological behavior of most of the drugs in use today. We will further compare the lead ALDH imaging agent to a previously validated PET radiotracer, designed at UCL for the noninvasive assessment of MDP1 activity, to determine their clinical utility. Following clinical translation, an imaging biomarker of treatment resistance will help stratify patients into those suitable for second-line therapy, with high likelihood of response, allowing long term personalised patient management and the possibility of reducing mortality and morbidity.
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Grant Details
Amount Awarded | 1137496 |
Applicant Surname | Witney |
Approval Committee | Sir Henry Dale Fellowship Interview Committee |
Award Date | 2015-05-27T00:00:00+00:00 |
Financial Year | 2014/15 |
Grant Programme: Title | Sir Henry Dale Fellowship |
Internal ID | 107610/Z/15/Z |
Lead Applicant | Dr Timothy Witney |
Partnership Name | Royal Society/Wellcome Trust Sir Henry Dale Fellowship |
Partnership Value | 1137496 |
Planned Dates: End Date | 2018-10-21T00:00:00+00:00 |
Planned Dates: Start Date | 2015-07-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |
Sponsor(s) | Prof Raymond MacAllister |