Clock control of inflammation in the lung. (360G-Wellcome-107851_Z_15_Z)

£0

Circadian rhythms dominate virtually all aspects of human physiology. It is now established that disruption of the circadian clock has a profound impact on inflammation in both humans and in animal models. Unexpectedly, clock mediation of inflammatory responses extends not only to the magnitude of response, but also its sensitivity to anti-inflammatory glucocorticoid signals. This proposal focuses on pulmonary inflammation, and capitalises on unique genetic models and pharmacological tools devel oped by our group to address a fundamental question: How does the clock control host defence? Specifically, we will elucidate: 1: How time-keeping and inflammatory cells communicate to shape pulmonary immune response 2: How the molecular clock controls pro- and anti-inflammatory signalling within the lung 3: How clock regulation of epigenetic structure mediates inflammatory set point

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Grant Details

Amount Awarded 0
Applicant Surname Loudon
Approval Committee Science Interview Panel
Award Date 2015-07-07T00:00:00+00:00
Financial Year 2014/15
Grant Programme: Title Investigator Award in Science
Internal ID 107851/Z/15/Z
Lead Applicant Prof Andrew Loudon
Partnership Value 0
Planned Dates: End Date 2022-12-31T00:00:00+00:00
Planned Dates: Start Date 2016-07-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North West