THE PHYSIOLOGICAL ROLE OF CLATHRIN LIGHT CHAIN DIVERSITY IN VERTEBRATES. (360G-Wellcome-107858_B_15_Z)

£51,200

Clathrin-coated vesicles (CCVs) influence cell-cell interaction for all eukaryotic organisms by mediating membrane traffic pathways that control receptor expression and organelle formation. The biochemistry of how clathrin polymerizes into a lattice to form a CCV is understood at a basic level, but how CCVs meet the transport challenges posed by specialized cargo and membrane variation in different vertebrate tissues is not fully defined. It is known that adaptor molecules incorporated into the clathrin coat are variable and have variable cargo specificity. However, recent studies suggest a new paradigm in which properties of the clathrin lattice itself, conferred by the light chain subunits, also influence coat selection of cargo. Although identified as obligate clathrin subunits 35 years ago, the functions of the clathrin light chains (CLCs), which display tissue-specific isoform variation, are not fully established. The emerging role for CLCs in a novel coat function and their ti ssue variability beg the overall question addressed here: How does the CLC component of the clathrin coat affect cargo transport and influence the physiological function of clathrin in vertebrates? Specific questions to be addressed through protein chemistry, cell biology and mouse genetics are Question 1: How do CLC isoforms affect the biochemical properties of clathrin? Question 2: How do CLCs affect cargo specificity of CCV transport? Question 3: How does CLC variability influenc e vertebrate tissue morphology and function?

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Grant Details

Amount Awarded 51200
Applicant Surname Brodsky
Award Date 2015-07-07T00:00:00+00:00
Financial Year 2014/15
Grant Programme: Title Investigator Award in Science
Internal ID 107858/B/15/Z
Lead Applicant Prof Frances Brodsky
Partnership Value 51200
Planned Dates: End Date 2021-01-01T00:00:00+00:00
Planned Dates: Start Date 2017-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London