Virus-Host interactions regulating HIV-1 replication in T cells. (360G-Wellcome-108079_Z_15_Z)

£1,305,749

My central research goal is to understand the cell biology of HIV-1 replication in CD4+ T lymphocytes - the main targets for the virus in vivo. Careful molecular delineation of how this process works will provide greater insight into virus infection of immune cells, advance understanding of HIV-1 pathogenesis and contribute fundamental knowledge about T cell function in health and disease; potentially informing future therapeutic strategies to eradicate the virus and reduce the pathological cons equences for the host. To this end, my research addresses the following core questions: 1) How does HIV-1 spread between T cells during infection? 2) What are the biological consequences of HIV-1 - T cell interactions for subsequent T cell function?

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Grant Details

Amount Awarded 1305749
Applicant Surname Jolly
Approval Committee Science Interview Panel
Award Date 2015-07-07T00:00:00+00:00
Financial Year 2014/15
Grant Programme: Title Investigator Award in Science
Internal ID 108079/Z/15/Z
Lead Applicant Prof Clare Jolly
Partnership Value 1305749
Planned Dates: End Date 2021-11-30T00:00:00+00:00
Planned Dates: Start Date 2015-09-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London