Virus-Host interactions regulating HIV-1 replication in T cells. (360G-Wellcome-108079_Z_15_Z)
My central research goal is to understand the cell biology of HIV-1 replication in CD4+ T lymphocytes - the main targets for the virus in vivo. Careful molecular delineation of how this process works will provide greater insight into virus infection of immune cells, advance understanding of HIV-1 pathogenesis and contribute fundamental knowledge about T cell function in health and disease; potentially informing future therapeutic strategies to eradicate the virus and reduce the pathological cons equences for the host. To this end, my research addresses the following core questions: 1) How does HIV-1 spread between T cells during infection? 2) What are the biological consequences of HIV-1 - T cell interactions for subsequent T cell function?
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Grant Details
Amount Awarded | 1305749 |
Applicant Surname | Jolly |
Approval Committee | Science Interview Panel |
Award Date | 2015-07-07T00:00:00+00:00 |
Financial Year | 2014/15 |
Grant Programme: Title | Investigator Award in Science |
Internal ID | 108079/Z/15/Z |
Lead Applicant | Prof Clare Jolly |
Partnership Value | 1305749 |
Planned Dates: End Date | 2021-11-30T00:00:00+00:00 |
Planned Dates: Start Date | 2015-09-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |