Monogenic diabetes in Iran. (360G-Wellcome-108101_Z_15_Z)

£93,819

The aim of this seed project is to establish a collaboration with hospital-based researchers in Iran to understand monogenic diabetes in this Middle Eastern country. This study is important: (i) The prevalence of diabetes and obesity is high in Iran; family history and clinical criteria used in Europe may not be useful in diagnosis. Correct diagnosis is important because monogenic forms can often be treated with oral agents rather than insulin. (ii) The rate of consanguinity is high; identificat ion of new recessive mutations/genes is easier in consanguineous families, which will inform us about the underlying mechanism and diagnostic tests for monogenic diabetes. (iii) This will be the first study of the genetics of monogenic diabetes in Iran using next generation sequencing and whole-exome sequencing. I work with one of the leading groups in monogenic diabetes (led by Professors Hattersley and Ellard). I aim to (i) Establish a collaboration with Iranian clinicians and set up cohorts of monogenic diabetes. (ii) Use advances in DNA sequencing to assess the role of known and novel genes in the pathogenesis of monogenic diabetes. (iii) Use known genetic variants and non-genetic biomarkers to help classify young patients into type 1 diabetes or likely monogenic diabetes.

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Grant Details

Amount Awarded 93819
Applicant Surname Yaghootkar
Approval Committee ERG1 Genetics, Genomics and Population Research
Award Date 2015-05-01T00:00:00+00:00
Financial Year 2014/15
Grant Programme: Title Seed Award in Science
Internal ID 108101/Z/15/Z
Lead Applicant Dr Hanieh Yaghootkar
Partnership Value 93819
Planned Dates: End Date 2018-07-01T00:00:00+00:00
Planned Dates: Start Date 2016-07-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South West