The Functional Genomics Cell Bank at St George's: extension of activities. (360G-Wellcome-108429_Z_15_Z)

Support is sought for the maintenance and further development of the [Wellcome Trust] Functional Genomics Cell Bank. This unique resource, established with the Trust's support, holds a large collection of mammalian cell lines, especially lines of mouse melanocytes (pigment cells) and melanoblasts carrying congenic pigmentary mutations. The melanocytic lineage is invaluable as a genetic model, because of the rich genetic resources of many defined murine coat-colour mutations, and their human homo logous loci. The Bank provides immortal melanocytes to hundreds of institutions worldwide. The cells are used to study the actions of the mutated genes, which affect many body systems besides pigmentation, thus fostering research widely relevant to human and animal health. The key objectives are: to preserve and expand the Bank's genetic resources, of incalculable value; and to continue and expand its other services. We will provide on request cells, advice and training in specialized culture techniques, and derivatives such as DNA. We will increase publicity and information about the Bank. We will establish further mutant melanocyte lines of specific current research interest, and will employ our specialized skills to collaborate with users where it will facilitate their research.