A novel biomarker platform for dementia research with single molecule sensitivity. (360G-Wellcome-108457_Z_15_Z)
Identification of biomarkers is increasingly important in diagnosis and therapeutic decision making in most areas of medicine and particularly so in neurological conditions due to difficulties of direct visualisation and tissue sampling of the central nervous system. Biomarkers are also critically important for clinical trial inclusion criteria and as outcome measures. Sensitive methods to measure markers are constantly sought and in clinical neuroscience cerebrospinal fluid (CSF) is one of the most promising biomarker matrices, although CSF volumes are often limited and not easily resampled. Biomarkers in CSF are at low concentration and so are not easily measured. A key objective is to develop novel biomarkers for core neuropathological changes in neurological diseases using ultrasensitive Simoa technology. The equipment requested is a fully automated analyser manufactured by Quanterix , the Simoa HD-1. Simoa (single molecule array) technology is based on standard immunochemical tec hniques and uses paramagnetic beads and standard reagents but is able to achieve much greater sensitivity than standard techniques due to the ability to trap single molecules in femtolitre volume wells allowing for a digital readout. measuring at the single molecule level. This can lead to up to 1000-fold better analytical sensitivity, compared to traditional ELISA techniques.
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Grant Details
Amount Awarded | 119531 |
Applicant Surname | Zetterberg |
Approval Committee | Multi-User Equipment Committee (inactive) |
Award Date | 2015-06-11T00:00:00+00:00 |
Financial Year | 2014/15 |
Grant Programme: Title | Multi-User Equipment Grant |
Internal ID | 108457/Z/15/Z |
Lead Applicant | Prof Henrik Zetterberg |
Other Applicant(s) | Dr Adrian Isaacs, Dr Edward Wild, Dr Jonathan Schott, Dr Simon Heales, Prof Jason Warren, Prof John Hardy, Prof Nicholas Wood, Prof Nick Fox, Prof Sarah Tabrizi |
Partnership Value | 119531 |
Planned Dates: End Date | 2016-07-12T00:00:00+00:00 |
Planned Dates: Start Date | 2015-07-13T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |