Modern Cryo-Electron Microscopy with Direct Electron Detection at the University of Leeds. (360G-Wellcome-108466_Z_15_Z)

£1,000,000

Funding is requested to buy a modern, cryo-capable, electron microscope to replace an outdated instrument at the end of its useful life. Data collection is currently slow and inefficient, and we cannot achieve the resolution that modern instruments allow. The new microscope will be more stable, automated, and equipped with a direct detector of the kind that is revolutionizing EM. We will also purchase the infrastructure to handle the enormous data flows that we will generate. This will transform electron microscopy in the Astbury Centre and support a wide range of biomedical projects in areas such as infection, degeneration and cancer. For 1M of Trust funds, and University investment of 1.7M, the new microscope will enable cutting-edge biological EM, including: 1) Pushing the structure determination of biological macromolecules (and their complexes) to the highest possible resolution, which in many cases will be close to atomic resolution (3-5 ). 2) Allowing us for the first time t o solve the structures of smaller macromolecules and complexes ( > 200-300 KDa) 3) Determining the structures of relatively lowly populated functional states in heterogeneous and/or dynamic systems 4) Performing tomography studies of unique biological events such as the entry of a virus into its host cell.

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Grant Details

Amount Awarded 1000000
Applicant Surname Ranson
Approval Committee Multi-User Equipment Committee (inactive)
Award Date 2015-06-11T00:00:00+00:00
Financial Year 2014/15
Grant Programme: Title Multi-User Equipment Grant
Internal ID 108466/Z/15/Z
Lead Applicant Prof Neil Ranson
Other Applicant(s) Dr Stephen Muench, Prof Adrian Goldman, Prof Adrian Whitehouse, Prof Alan Berry, Prof John Ladbury, Prof Mark Harris, Prof Paul Stewart, Prof Peter Stockley, Prof Sheena Radford
Partnership Value 1000000
Planned Dates: End Date 2021-02-28T00:00:00+00:00
Planned Dates: Start Date 2016-03-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Yorkshire and the Humber