Fracture union in HIV positive patients (360G-Wellcome-108715_Z_15_Z)

HIV and highly active antiretroviral therapy (HAART) have been shown to decrease bone mineral density and mineralisation. Researchers have suggested that they both contribute to the development of delayed bone union and nonunion following a fracture. However, the true effect of HIV and HAART on bone healing is very poorly understood. Our aim is to establish the effect of HIV and HAART on the fracture repair process, addressing three key goals: 1. To determine whether HIV-infected adults have a higher rate of delayed bone union and nonunion, compared to HIV-uninfected adults following a fracture 2. To establish whether HIV is a potential risk factor for the development of non-union after fracture surgery 3. To investigate the effect of HAART on the fracture repair process These goals will be addressed by two studies: Goal 1 will be achieved through a case-cohort study investigating bone union (controls) and delayed bone union (cases) in adults following fracture surgery, by HIV s tatus (exposure). Goal 2 and 3 will be addressed through an in vivo study. The rate of nonunion, using an established fracture model, in HIV-1 transgenic rats treated with HAART, will be compared to an untreated control and HIV-1 transgenic group.

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Grant Details

Amount Awarded 432264
Applicant Surname Graham
Approval Committee International Interview Committee
Award Date 2015-06-17T00:00:00+00:00
Financial Year 2014/15
Grant Programme: Title Research Training Fellowship
Internal ID 108715/Z/15/Z
Lead Applicant Dr Simon Graham
Partnership Value 432264
Planned Dates: End Date 2022-03-07T00:00:00+00:00
Planned Dates: Start Date 2017-02-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North West
Sponsor(s) Prof David Lalloo, Prof Hamish Simpson, Prof Sithombo Maqungo