Fracture union in HIV positive patients (360G-Wellcome-108715_Z_15_Z)
HIV and highly active antiretroviral therapy (HAART) have been shown to decrease bone mineral density and mineralisation. Researchers have suggested that they both contribute to the development of delayed bone union and nonunion following a fracture. However, the true effect of HIV and HAART on bone healing is very poorly understood. Our aim is to establish the effect of HIV and HAART on the fracture repair process, addressing three key goals: 1. To determine whether HIV-infected adults have a higher rate of delayed bone union and nonunion, compared to HIV-uninfected adults following a fracture 2. To establish whether HIV is a potential risk factor for the development of non-union after fracture surgery 3. To investigate the effect of HAART on the fracture repair process These goals will be addressed by two studies: Goal 1 will be achieved through a case-cohort study investigating bone union (controls) and delayed bone union (cases) in adults following fracture surgery, by HIV s tatus (exposure). Goal 2 and 3 will be addressed through an in vivo study. The rate of nonunion, using an established fracture model, in HIV-1 transgenic rats treated with HAART, will be compared to an untreated control and HIV-1 transgenic group.
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Grant Details
Amount Awarded | 432264 |
Applicant Surname | Graham |
Approval Committee | International Interview Committee |
Award Date | 2015-06-17T00:00:00+00:00 |
Financial Year | 2014/15 |
Grant Programme: Title | Research Training Fellowship |
Internal ID | 108715/Z/15/Z |
Lead Applicant | Dr Simon Graham |
Partnership Value | 432264 |
Planned Dates: End Date | 2022-03-07T00:00:00+00:00 |
Planned Dates: Start Date | 2017-02-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | North West |
Sponsor(s) | Prof David Lalloo, Prof Hamish Simpson, Prof Sithombo Maqungo |