Characterising the composition of low temperature air plasma to assess applications for wound infection and healing (360G-Wellcome-109316_Z_15_A)

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Wound infections, coupled with increasing antibiotic resistance are a global issue, and low temperature plasma (LTP) presents an interesting alternative treatment strategy as it has been shown to be bactericidal and to promote wound healing. LTP is characterised by a low degree of ionisation, a non-thermodynamic equilibrium and a dry reactive environment. Here, we propose the development of a nano-/microsecond pulsed, kilohertz repetition frequency air plasma. The plasma will be characterised both experimentally and computationally, in terms of reactive oxygen and nitrogen species concentrations, optical emission and temperature. This is of interest when considering LTP as a low-cost wound treatment, as air plasma should not require expensive bottled gases, thus decreasing running costs and increasing transportability. In terms of biological interaction, the aim is to use the characterised plasma to correlate plasma composition with (1) the difference in tolerance to oxidative stress between bacterial and eukaryotic cells and (2) the effects of plasma on the dynamics of healing-related gene expression in epithelial cells post wounding. The project should offer new insights into the development and characterisation of air plasmas, and their potential for use in biomedical applications, in particular wound infection and healing.

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Grant Details

Amount Awarded 0
Applicant Surname Davies
Approval Committee Internal Decision Panel
Award Date 2017-01-31T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title PhD Studentship (Basic)
Internal ID 109316/Z/15/A
Lead Applicant Miss Helen Davies
Partnership Value 0
Planned Dates: End Date 2019-10-01T00:00:00+00:00
Planned Dates: Start Date 2016-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Yorkshire and the Humber