Biological and lifestyle predictors of outcomes in people with head and neck cancer (360G-Wellcome-110021_Z_15_A)

£0

Using data collected from a prospective clinical cohort of people with head and neck cancer (HNC)-Head and Neck 5000 (H & N5000), I will examine the potential value of baseline (pre-treatment) biological, clinical and lifestyle factors in predicting HNC prognosis at one year and three years post diagnosis. I will look at the association between tobacco and alcohol consumption and measures of outcome- overall survival, disease-free survival, metastasis, and second primary tumour (SPT) development. I will investigate whether behavioural change i.e. abstaining from, or reducing the consumption of alcohol and tobacco improves clinical and self-reported health outcomes in this population. To better understand how smoking and drinking behaviours may be influencing prognosis, I will analyse the methylation and metabolite profiles of baseline blood samples. I will explore whether there is an association between DNA methylation and metabolite levels and tobacco and alcohol consumption. Should I identify sites that are differentially methylated in smokers and drinkers, or metabolites that vary by smoking/drinking intake, I will evaluate whether they could potentially act as biomarkers for cancer progression and survival. I will look to develop a risk score that incorporates clinical, biological and lifestyle risk factors, which could be developed for use in clinical decision-making.

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Grant Details

Amount Awarded 0
Applicant Surname Beynon
Approval Committee Internal Decision Panel
Award Date 2017-01-31T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title PhD Studentship (Basic)
Internal ID 110021/Z/15/A
Lead Applicant Miss Rhona Beynon
Partnership Value 0
Planned Dates: End Date 2020-03-30T00:00:00+00:00
Planned Dates: Start Date 2016-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South West