How does a cell complete genome replication? (360G-Wellcome-110064_Z_15_Z)
My long-term goal is to determine how cells faithfully complete genome replication. Errors in DNA replication occur on single molecules in individual cells; however these errors can be hidden from view in genomic approaches that look at data from populations of several million cells. I will pioneer revolutionary single-molecule technologies that will allow me to discover how human cells complete genome replication. My questions are: 1) How is origin activity regulated to ensure complete ge nome replication? 1a) Where are DNA replication origins in human cells? 1b) How is origin activity coordinated to ensure complete genome replication? 1c) How does DNA replication origin activity respond to perturbations? 2) What happens if an insufficient number of replication origins activate? 2a) What happens to an unreplicated region of the genome? 2b) What mechanisms aid genome stability when replication is incomplete?
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Grant Details
| Amount Awarded | 1279523 |
| Applicant Surname | Nieduszynski |
| Approval Committee | Science Interview Panel |
| Award Date | 2015-12-02T00:00:00+00:00 |
| Financial Year | 2015/16 |
| Grant Programme: Title | Investigator Award in Science |
| Internal ID | 110064/Z/15/Z |
| Lead Applicant | Prof Conrad Nieduszynski |
| Partnership Value | 1279523 |
| Planned Dates: End Date | 2019-10-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2016-06-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South East |