New perspectives for anti-viral therapy: The regulatory roles of genomic RNA in virus assembly, infection and evolution. (360G-Wellcome-110146_Z_15_Z)
We will exploit our discovery of fundamental mechanisms regulating assembly in important single-stranded RNA viruses based on multiple, dispersed RNA-protein interactions (packaging signals, PSs) to: 1. Determine how genomic RNAs play regulatory roles in the mechanisms of virus assembly, maturation and host cell invasion. 2. Determine which viral and host components are needed to develop a quantitative systems understanding of assembly in vivo. 3. Analyse how viruses may evade anti-v iral strategies targeting PSs functions, triggering the occurrence of mutant strains. This paves the way for novel forms of anti-viral intervention.
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Grant Details
| Amount Awarded | 620762 |
| Applicant Surname | Twarock |
| Approval Committee | Science Interview Panel |
| Award Date | 2015-12-02T00:00:00+00:00 |
| Financial Year | 2015/16 |
| Grant Programme: Title | Investigator Award in Science |
| Internal ID | 110146/Z/15/Z |
| Lead Applicant | Prof Reidun Twarock |
| Other Applicant(s) | Prof Peter Stockley |
| Partnership Value | 620762 |
| Planned Dates: End Date | 2023-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2016-05-13T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Yorkshire and the Humber |