Identification of substrates and roles in virulence of the Staphylococcus aureus Ess protein secretion system. (360G-Wellcome-110183_Z_15_Z)
1. What are your research questions? How does the Ess secretion system modulate Staphylococcus aureus pathogenesis? Staphylococcus aureus is a major antibiotic-resistant bacterial pathogen. Although it is frequently found as a human commensal organism, it can cause a number of life-threatening diseases including necrotising fasciitis and pneumonia. Our recent data, along with findings from others have shown that the Ess or Type VII protein secretion system plays a very significant role in the ability of S. aureus to establish persistent infections. Our specific questions are: 1. What is the repertoire of effector proteins secreted by the Ess system in S. aureus? 2. Which of these secreted effectors are important for causing disease? 3. What are the biological activities of these secreted proteins? 4. Can we exploit our knowledge to develop the Ess system as a potential antibacterial target?
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Grant Details
| Amount Awarded | 1199165 |
| Applicant Surname | Palmer |
| Approval Committee | Science Interview Panel |
| Award Date | 2015-12-02T00:00:00+00:00 |
| Financial Year | 2015/16 |
| Grant Programme: Title | Investigator Award in Science |
| Internal ID | 110183/Z/15/Z |
| Lead Applicant | Prof Tracy Palmer |
| Partnership Value | 1199165 |
| Planned Dates: End Date | 2018-07-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2016-07-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Scotland |