Development of a Generalized Modules for Membrane Antigens vaccine against gonococcus (360G-Wellcome-201075_Z_16_Z)

£167,275

There are 106 million cases of gonorrhoea each year that disproportionately affect women and new-born children, particularly in low-income countries. With increasing levels of anti-microbial resistance, there are growing concerns about untreatable gonorrhoea. There is a clear need for a vaccine against gonorrhoea, but none is available. Cal’s solution is to develop a Generalized Modules for Membrane Antigens (GMMA) vaccine candidate for gonorrhoea. It will exploit the ability of Gram-negative bacteria to shed outer membrane blebs displaying antigens including lipo-oligosaccharide and multiple membrane proteins which are targets of functional/bactericidal immune responses. GMMA are easy to manufacture and highly affordable. They are more immunogenic than equivalent subunit vaccines, having an adjuvant effect through delivery of signals to the innate immune system. The key goal of the project is to establish preclinical proof-of-concept for suitability of the GMMA approach for vaccine against gonorrhoea. The future potential healthcare benefits are a major global reduction in gonorrhoea, and improvement of reproductive and maternal/new-born health.

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Grant Details

Amount Awarded 167275
Applicant Surname MacLennan
Approval Committee Pathfinders Assessment Group
Award Date 2016-01-13T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Pathfinder Award
Internal ID 201075/Z/16/Z
Lead Applicant Prof Calman Alexander MacLennan
Partnership Value 167275
Planned Dates: End Date 2019-03-31T00:00:00+00:00
Planned Dates: Start Date 2016-05-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East