Development of a Generalized Modules for Membrane Antigens vaccine against gonococcus (360G-Wellcome-201075_Z_16_Z)
There are 106 million cases of gonorrhoea each year that disproportionately affect women and new-born children, particularly in low-income countries. With increasing levels of anti-microbial resistance, there are growing concerns about untreatable gonorrhoea. There is a clear need for a vaccine against gonorrhoea, but none is available. Cal’s solution is to develop a Generalized Modules for Membrane Antigens (GMMA) vaccine candidate for gonorrhoea. It will exploit the ability of Gram-negative bacteria to shed outer membrane blebs displaying antigens including lipo-oligosaccharide and multiple membrane proteins which are targets of functional/bactericidal immune responses. GMMA are easy to manufacture and highly affordable. They are more immunogenic than equivalent subunit vaccines, having an adjuvant effect through delivery of signals to the innate immune system. The key goal of the project is to establish preclinical proof-of-concept for suitability of the GMMA approach for vaccine against gonorrhoea. The future potential healthcare benefits are a major global reduction in gonorrhoea, and improvement of reproductive and maternal/new-born health.
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Grant Details
Amount Awarded | 167275 |
Applicant Surname | MacLennan |
Approval Committee | Pathfinders Assessment Group |
Award Date | 2016-01-13T00:00:00+00:00 |
Financial Year | 2015/16 |
Grant Programme: Title | Pathfinder Award |
Internal ID | 201075/Z/16/Z |
Lead Applicant | Prof Calman Alexander MacLennan |
Partnership Value | 167275 |
Planned Dates: End Date | 2019-03-31T00:00:00+00:00 |
Planned Dates: Start Date | 2016-05-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South East |