Evaluation of feasibility of assessing liver function during ex situ liver perfusion using microdialysis (360G-Wellcome-202077_Z_16_Z)
Each year 15% of patients on the UK liver transplant waiting list die awaiting a donor liver, while a significant proportion of livers go unused because clinicians are unsure that the liver would provide life sustaining function. We are now able to perfuse a liver ex situ with oxygenated blood while evaluating markers of damage and function, enabling better assessment of organ viability. Microdialysis is a method in routine use in neurosurgery to evaluate brain metabolism following trauma, and involves passing a fine dialysis catheter into the brain parenchyma and perfusing it with an isotonic perfusate and examining the dialysate for metabolic markers such as glucose, lactate, and pyruvate. It can also be used to interrogate metabolism by introducing labeled substrates. Microdialysis has been used to study liver transplants post transplant, but has not been used to evaluate function ex situ where its relatively rapid readout may facilitate early and accurate decision making.This project will examine the feasibility of using microdialysis in perfused livers. Human livers that have been declined for transplantation will be studied and the optimal technique developed. Microdialysis results will be correlated with perfusate chemistry (lactate fall, maintenance of pH, ALT, AST) and metabolomic profile.
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Grant Details
Amount Awarded | 2000 |
Applicant Surname | Pley |
Approval Committee | Internal Decision Panel for C&S |
Award Date | 2016-04-01T00:00:00+00:00 |
Financial Year | 2015/16 |
Grant Programme: Title | Vacation Scholarships |
Internal ID | 202077/Z/16/Z |
Lead Applicant | Miss Caitlin Pley |
Partnership Value | 2000 |
Planned Dates: End Date | 2016-08-20T00:00:00+00:00 |
Planned Dates: Start Date | 2016-06-20T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |