Psychophysics of predictive motor control: a novel model of post-stroke fatigue (360G-Wellcome-202346_Z_16_Z)

£905,754

Fatigue in neurological conditions, unlike exercise induced fatigue, is chronic, irreversible and does not arise from altered sensory afferent input from peripheral musculature. A distinctive feature of such fatigue is requirement of high effort for everyday activity. Normally, everyday activity feels relatively effortless. This is due to re-afferent sensory feedback from voluntary movement being attenuated under normal circumstances (sensory attenuation). I propose that neurological perceptual fatigue is a result of poor attenuation of re-afferent sensory feedback making even the simplest of movements feel effortful. Using a combination of behavioural and electroencephalography techniques, in a series of systematic experiments, I will study the interaction between self-reported fatigue, effort, behavioural and neural correlates of sensory attenuation. Furthermore, using brain stimulation techniques I will modulate sensory attenuation to determine the direction of causality between fatigue and neural processing. I will study chronic stroke survivors where post-stroke fatigue is a major problem. Fatigue is commonly seen as a neuropsychiatric symptom in neurological conditions and what I propose is a significant shift away from fatigue as a psychiatric problem and towards neurological fatigue being a sensorimotor disorder. The proposed project is also likely to identify a potential therapeutic target to develop interventions for neurological fatigue.

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Grant Details

Amount Awarded 905754
Applicant Surname Kuppuswamy
Approval Committee Sir Henry Dale Fellowship Interview Committee
Award Date 2016-06-01T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Sir Henry Dale Fellowship
Internal ID 202346/Z/16/Z
Lead Applicant Dr Annapoorna Kuppuswamy
Partnership Name Royal Society/Wellcome Trust Sir Henry Dale Fellowship
Partnership Value 905754
Planned Dates: End Date 2022-09-30T00:00:00+00:00
Planned Dates: Start Date 2016-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Linda Greensmith