Characterisation of immune responses to novel malaria pre-erythrocytic stage antigens (360G-Wellcome-202698_Z_16_Z)
The feasibility of malaria vaccination was initially established in mouse models 45 years ago by multiple immunisations of irradiated Plasmodium berghei sporozoites (gamma-PbSpz), which completely protected against parasite challenge. The elicited protection targets the pre-erythrocytic stages of the parasite, i.e. sporozoites and exo-erythrocytic forms (EEFs or liver stages), and is mediated primarily by cytotoxic (CD8+) T cells and neutralising antibodies. However, the paucity of endogenous antigenic targets for recognition by these immune effector mechanisms has limited in-depth characterisation of the mechanisms underlying sporozoite-induced protection. The circumsporozoite protein (CSP), the basis of the most advanced malaria vaccine candidate to date, is an immunodominant antigen only in the BALB/c immunisation and infection model. However, several lines of evidence suggest that protection against pre-erythrocytic stages can be independent of CSP-specific immune responses. These findings warrant the search for other antigenic targets against malaria pre-erythrocytic stages. The Hafalla group has made considerable advances in identifying novel targets of T cells and antibodies against malaria pre-erythrocytic stages. My goal is to characterise some antigens using defined immunological assays. This research endeavor will contribute to a comprehensive understanding of immune responses to malaria pre-erythrocytic stages and will reveal correlates of protection against this infection.
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Grant Details
Amount Awarded | 1750 |
Applicant Surname | Fernandes |
Approval Committee | Internal Decision Panel for C&S |
Award Date | 2016-04-01T00:00:00+00:00 |
Financial Year | 2015/16 |
Grant Programme: Title | Vacation Scholarships |
Internal ID | 202698/Z/16/Z |
Lead Applicant | Miss Victoria Fernandes |
Partnership Value | 1750 |
Planned Dates: End Date | 2016-08-14T00:00:00+00:00 |
Planned Dates: Start Date | 2016-06-15T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |