The NPC lysosomal pathway as a novel hub in host: pathogen interactions (360G-Wellcome-202834_Z_16_Z)
We have made the novel and unexpected discovery that the lysosomal pathway deficient in a rare genetic lysosomal storage disease (Niemann-Pick type C (NPC)) is a hub targeted by multiple human pathogens, including Mycobaterium tuberculosis and Ebola. Our aims are therefore to: 1) understand the molecular mechanisms by which pathogenic microbes manipulate NPC1 function, 2) determine the breadth of human pathogens that have evolved strategies to target this protein to promote their survival, 3) interrogate NPC1 and acidic store Ca2+ involvement in Ebola infection and further the identification of anti-viral molecules and 4) define the roles that lysosomal Ca2+stores play in regulating inflammatory responses. We anticipate the insights gained from these studies will expedite development of new approaches to infectious and inflammatory disease treatment.
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Grant Details
Amount Awarded | 1681554 |
Applicant Surname | Platt |
Approval Committee | Science Interview Panel |
Award Date | 2016-07-05T00:00:00+00:00 |
Financial Year | 2015/16 |
Grant Programme: Title | Investigator Award in Science |
Internal ID | 202834/Z/16/Z |
Lead Applicant | Prof Frances Platt |
Partnership Value | 1681554 |
Planned Dates: End Date | 2022-02-28T00:00:00+00:00 |
Planned Dates: Start Date | 2016-09-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South East |