The NPC lysosomal pathway as a novel hub in host: pathogen interactions (360G-Wellcome-202834_Z_16_Z)

£1,681,554

We have made the novel and unexpected discovery that the lysosomal pathway deficient in a rare genetic lysosomal storage disease (Niemann-Pick type C (NPC)) is a hub targeted by multiple human pathogens, including Mycobaterium tuberculosis and Ebola. Our aims are therefore to: 1) understand the molecular mechanisms by which pathogenic microbes manipulate NPC1 function, 2) determine the breadth of human pathogens that have evolved strategies to target this protein to promote their survival, 3) interrogate NPC1 and acidic store Ca2+ involvement in Ebola infection and further the identification of anti-viral molecules and 4) define the roles that lysosomal Ca2+stores play in regulating inflammatory responses. We anticipate the insights gained from these studies will expedite development of new approaches to infectious and inflammatory disease treatment.

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Grant Details

Amount Awarded 1681554
Applicant Surname Platt
Approval Committee Science Interview Panel
Award Date 2016-07-05T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Investigator Award in Science
Internal ID 202834/Z/16/Z
Lead Applicant Prof Frances Platt
Partnership Value 1681554
Planned Dates: End Date 2022-02-28T00:00:00+00:00
Planned Dates: Start Date 2016-09-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East