An electron cryo-microscopy resource for macromolecular structure determination in the University of Cambridge (360G-Wellcome-202905_Z_16_Z)
We seek to establish an advanced electron cryo-microscopy (cryo-EM) facility dedicated to structural studies of biological macromolecular assemblies. The facility would provide a revolutionary new tool to the large structural biology community in the University that would enable acquisition of critical data in support of a wide and diverse range of projects tackling fundamental problems in molecular biology relevant to human health. Currently, the named applicants primarily use X-ray crystallography to study large assemblies, but many of these samples cannot be readily crystallised. The recent development of a new generation of direct electron detectors, together with sophisticated data-processing software, has dramatically improved cryo-EM analysis, which now achieves routinely sub-nanometer resolution. However, we lack access to such a facility in the University. A wide range of projects will benefit from the proposed facility, including studies of multi-drug efflux membrane transporters; assemblies of RNA metabolism; complexes regulating chromatin structure, DNA replication and repair; mitochondrial complex I and its roles in human disease; ribosome assembly defects in bone marrow failure; presenilin complexes and other assemblies related to neurodegeneration; human neurotransmitter transporters and G-protein coupled receptors; transport vesicle and organelle biogenesis; molecular mechanism of ATP synthase; and methods development in EM of biological macromolecules.
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Grant Details
Amount Awarded | 1000000 |
Applicant Surname | Luisi |
Approval Committee | Multi-User Equipment and Technology Development Committee |
Award Date | 2016-06-16T00:00:00+00:00 |
Financial Year | 2015/16 |
Grant Programme: Title | Multi-User Equipment Grant |
Internal ID | 202905/Z/16/Z |
Lead Applicant | Prof Ben Luisi |
Other Applicant(s) | Dr Judy Hirst, Dr Simone Weyand, Prof Alan Warren, Prof David Owen, Prof Ernest Laue, Prof Luca Pellegrini, Prof Peter St George-Hyslop, Prof Randy Read, Prof Sir John Walker |
Partnership Value | 1000000 |
Planned Dates: End Date | 2021-12-19T00:00:00+00:00 |
Planned Dates: Start Date | 2016-12-19T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |