In vivo microscopy system to probe microbiome link to inflammation (360G-Wellcome-202911_Z_16_Z)
The microbiome has been shown to impact immune responses in the gut and throughout the body. While there are many multiphoton microscopes available in the UK and at the University of Oxford, none of these systems combine the features necessary to image fluorescent reporters in tissues under varying conditions of inflammation or are juxtaposed to a state of the art germ free animal facility. Wellcome Trust funded investigators at the University of Oxford request a microscope specialized for in vivo imaging of inflammatory processes in multiple impacted tissues. The special features of the system will be large field of view, high scan rate and innovative use of a spectral detector array and dual laser multiphoton excitation. The system will be situated in the Kennedy Trust of Rheumatology animal facility, which will include both specific pathogen free and germ-free/gnotobiotic mice. We request a Zeiss 880 laser scanning microscope with non-descanned and spectral GaAsP detectors with a set of conventional lasers to combine the complementary strengths of multiphoton and single photon excitation with conventional non-descanned detectors and highly sensitive spectral detectors that can be used in different combinations to enable flexible imaging approaches for challenging inflamed tissues.
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Grant Details
Amount Awarded | 284088 |
Applicant Surname | Dustin |
Approval Committee | Multi-User Equipment and Technology Development Committee |
Award Date | 2016-06-16T00:00:00+00:00 |
Financial Year | 2015/16 |
Grant Programme: Title | Multi-User Equipment Grant |
Internal ID | 202911/Z/16/Z |
Lead Applicant | Prof Michael Dustin |
Other Applicant(s) | Dr Audrey Gerard, Dr Francis Szele, Dr Tal Arnon, Prof Alison Simmons, Prof David Bennett, Prof Fiona Powrie, Prof Graham Ogg, Prof Kevin Maloy, Prof Paul Klenerman |
Partnership Value | 284088 |
Planned Dates: End Date | 2017-06-28T00:00:00+00:00 |
Planned Dates: Start Date | 2016-06-28T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South East |