Optical Cannula: Development of a tool for studying the inside of tubular organs under physiologically relevant conditions by imaging from within (360G-Wellcome-202924_B_16_Z)
Building on our recent imaging advances (refs-1-4), we will develop an optical platform to provide imaging access inside blood vessels and ‘hollow organs’ ( within. Advanced confocal and widefield microscopy techniques will be combined with focus-locking and adapive field-curvature correction to facilitate large-field (hundreds of cells) high-resolution imaging of the deepest, hard to access, layers of blood vessels, overcoming the small image fields, and imaging aberrations associated with conventional approaches. Automated data collection and analysis will provide high throughput ex vivo imaging in a physiologically intact manner not previously possible. Validating our technology in both our labs, and those of our project partners, we will iteratively refine and develop our platform for use on all pathological conditions linked to cardiovascular disease, and explore uses with other tubular organs. Wider dissemination of our platform will be assured through open access portals. Our project will deliver organ scale, physiologically relevant high resolution and high speed imaging, integrated data extraction and high-throughput analytical capacity. These breakthroughs will stimulate new understandings of cardiovascular disease with immediate impact on biomedical investigations.
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Grant Details
Amount Awarded | 301557 |
Applicant Surname | Girkin |
Award Date | 2016-06-16T00:00:00+00:00 |
Financial Year | 2015/16 |
Grant Programme: Title | Technology Development Grant |
Internal ID | 202924/B/16/Z |
Lead Applicant | Prof John Girkin |
Other Applicant(s) | Dr Christopher Saunter, Prof John Girkin |
Partnership Value | 301557 |
Planned Dates: End Date | 2020-10-01T00:00:00+00:00 |
Planned Dates: Start Date | 2017-04-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | North East |