Optical Cannula: Development of a tool for studying the inside of tubular organs under physiologically relevant conditions by imaging from within (360G-Wellcome-202924_B_16_Z)

£301,557

Building on our recent imaging advances (refs-1-4), we will develop an optical platform to provide imaging access inside blood vessels and ‘hollow organs’ ( within. Advanced confocal and widefield microscopy techniques will be combined with focus-locking and adapive field-curvature correction to facilitate large-field (hundreds of cells) high-resolution imaging of the deepest, hard to access, layers of blood vessels, overcoming the small image fields, and imaging aberrations associated with conventional approaches. Automated data collection and analysis will provide high throughput ex vivo imaging in a physiologically intact manner not previously possible. Validating our technology in both our labs, and those of our project partners, we will iteratively refine and develop our platform for use on all pathological conditions linked to cardiovascular disease, and explore uses with other tubular organs. Wider dissemination of our platform will be assured through open access portals. Our project will deliver organ scale, physiologically relevant high resolution and high speed imaging, integrated data extraction and high-throughput analytical capacity. These breakthroughs will stimulate new understandings of cardiovascular disease with immediate impact on biomedical investigations.

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Grant Details

Amount Awarded 301557
Applicant Surname Girkin
Award Date 2016-06-16T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Technology Development Grant
Internal ID 202924/B/16/Z
Lead Applicant Prof John Girkin
Other Applicant(s) Dr Christopher Saunter, Prof John Girkin
Partnership Value 301557
Planned Dates: End Date 2020-10-01T00:00:00+00:00
Planned Dates: Start Date 2017-04-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North East