Determination of the prevalence breast cancer predisposition genes in South East Asian women and development of an Asian polygenic risk assessment tool (360G-Wellcome-203477_B_16_Z)

£555,752

Breast cancer is rising rapidly in Asia and is the most common cause of cancer related deaths in Malaysia. Notably, whereas 80% of breast cancer in the UK occurs in post-menopausal women, only 40% occurs in post-menopausal women in Malaysia, and the proportion of risk attributable to genetic factors is likely to be correspondingly higher. In the absence of population-based screening, targeted screening provides a cost-effective alternative to reducing breast cancer mortality. Unfortunately, there remains a significant gap in knowledge and access to counseling and testing of BRCA1, BRCA2 and other cancer predisposition genes in most of Asia. With the decreasing cost of genetic testing, there is an opportunity to bridge that gap. We plan to: (1) characterise the prevalence of genetic susceptibility to breast cancer in the South East Asian population in Malaysia and Singapore; (2) provide risk estimates for BRCA1 and BRCA2 in our population; and (3) calibrate risk assessment models to accurately predict an individual’s risk of carrying germline alterations and their risk of cancer. The findings of this research will enable shared decision making and inform the development of appropriate management to ensure that healthcare resources can be used efficiently for targeted screening and prevention.

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Grant Details

Amount Awarded 555752
Applicant Surname Easton
Approval Committee Science Interview Panel
Award Date 2016-07-05T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Collaborative Award in Science
Internal ID 203477/B/16/Z
Lead Applicant Prof Douglas Easton
Partnership Value 555752
Planned Dates: End Date 2020-11-01T00:00:00+00:00
Planned Dates: Start Date 2017-05-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England