Grb2-mediated regulation of miRNA maturation in the basal state. (360G-Wellcome-203745_Z_16_A)
Cancers develop as a result of many interacting factors. Two such factors are cell stress and microRNA (miRNA) expression. Cell stress causes fluctuations in protein levels, which can perturb the proper functioning of the cell. miRNAs silence specific genes, and therefore can induce changes within the cell which cause them to become cancerous. However, little is known about how miRNA expression is altered. I aim to investigate a novel mechanism of miRNA regulation, which may be perturbed by cell stress. I will determine how the levels and activity of key components in miRNA biogenesis are altered in cells expressing different proteins and which have been subject to different stress conditions, using a range of in vitro, cell-based and biophysical approaches. I will also perform several screens to identify key microRNAs regulated by this mechanism, and how their expression changes with cell stress. This work will reveal new avenues for cancer therapy and help us to target cancer with a fresh perspective.
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Grant Details
| Amount Awarded |
0
|
| Applicant Surname | Stainthorp |
| Approval Committee | Internal Decision Panel |
| Award Date | 2018-09-30T00:00:00+00:00 |
| Financial Year | 2017/18 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 203745/Z/16/A |
| Lead Applicant | Ms Amy Stainthorp |
| Partnership Value | 0 |
| Planned Dates: End Date | 2020-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2017-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Yorkshire and the Humber |