Bridging the glial scar in spinal cord injury with a stem-cell based CNS graft (360G-Wellcome-203760_Z_16_A)
Spinal cord injury leads to paralysis of motor function as well as internal organ dysfunction. No current treatments are capable of restoring function reliably, if at all. We aim to construct a stem-cell based graft with therapeutic genes to bridge the gap produced during contusion injury. We will use mouse embryonic stem cells to derive specific neuronal populations involved in locomotion to treat spinal cord injury in a mouse model. The graft will be supplemented with therapeutic genes that will enhance neuronal survival, integration and functioning when transplanted. This will be measured several weeks after transplantation. Behavioural tests will be performed to evaluate motor function recovery. The study will help to advance in cellular therapies for spinal cord injury by using a combination of techniques that address previous failures in animal studies and clinical trials.
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Grant Details
| Amount Awarded |
0
|
| Applicant Surname | Berzanskyte |
| Approval Committee | Internal Decision Panel |
| Award Date | 2018-09-30T00:00:00+00:00 |
| Financial Year | 2017/18 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 203760/Z/16/A |
| Lead Applicant | Miss Ieva Berzanskyte |
| Partnership Value | 0 |
| Planned Dates: End Date | 2020-10-01T00:00:00+00:00 |
| Planned Dates: Start Date | 2016-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |