Structural Characterisation of the Orthobunyaviral Surface Glycoproteins (360G-Wellcome-203797_Z_16_A)
Orthobunyaviruses present medical and economical threats as they cause haemorrhagic fever and encephalitis in human, and abortion and stillbirth in livestock. Currently, little is known about how orthobunyaviruses infect their hosts and how they achieve cross-species transmission from anthropods to humans. My DPhil research focuses on structurally characterising the glycoproteins utilised by the orthobunyaviruses for infection and screening for neutralising antibodies. Using X-ray crystallography and electron microscopy techniques, I aim to contribute to a more complete understanding of orthobunyavirus-host cell attachment, intracellular trafficking, and membrane fusion. Ultimately, knowledge of host-cell entry mechanism will aid the development of vaccines and inhibitive peptides.
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Grant Details
| Amount Awarded |
0
|
| Applicant Surname | Ng |
| Approval Committee | Internal Decision Panel |
| Award Date | 2018-09-30T00:00:00+00:00 |
| Financial Year | 2017/18 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 203797/Z/16/A |
| Lead Applicant | Mr Weng Ng |
| Partnership Value | 0 |
| Planned Dates: End Date | 2020-09-29T00:00:00+00:00 |
| Planned Dates: Start Date | 2017-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South East |