Autophagy in the interplay between haematopoiesis and the bone marrow niche (360G-Wellcome-203803_Z_17_A)

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Autophagy (greek ‘self-eating’) is a cellular recycling process, which can provide new building blocks and energy to cells. Immune cells require autophagy for their differentiation, maintenance and function. Hence, decreased autophagic flux, which occurs naturally during aging, results in diminished immune function. The effect of autophagy in immune cells is particularly apparent in immune cells that permanently live or are generated in the bone marrow (BM). We aim to understand how autophagy regulates the interplay of immune cells and the BM environment. First, we aim to deplete autophagy in hematopoietic stem cells using genetic models and assess the effects on supporting cells in the bone marrow. For this we will use global and bioinformatic tools to study the BM composition based on both, gene expression and metabolite production. Second, we aim to deplete autophagy from bone marrow adipocytes, a subset of cells known to be able to provide building blocks and metabolites such as fatty acids to surrounding cells. We will study normal hematopoiesis and long-lived immune responses in this new mouse model. Findings from this project will be key to identify better conditions for hematopoietic stem cell transplantations and counteract negative effects of aging including inflammation.

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Grant Details

Amount Awarded 0
Applicant Surname Richter
Approval Committee Internal Decision Panel
Award Date 2018-09-30T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title PhD Studentship (Basic)
Internal ID 203803/Z/17/A
Lead Applicant Mr Felix Richter
Partnership Value 0
Planned Dates: End Date 2020-09-30T00:00:00+00:00
Planned Dates: Start Date 2017-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East